This table provides information on the status of harmonization or standardization of measurands. Additional information regarding the medical impact and harmonization status is available by clicking on the measurand name. The harmonization status shown in the table reflects the situation in economically well developed countries and other geographic areas when measurement procedures supplied by global IVD manufactures are used. The harmonization status may be different when reagents, calibrators and instruments from other suppliers are used.

The medical impact of harmonization, or priority for harmonization, is based on the influence of non-harmonized results on potential medical errors when interpreting a result for a measurand.

Harmonization status: 

  • Active means an organization is implementing a harmonization project.
  • Adequate/Maintain means the current harmonization is suitable for medical decisions and existing reference systems must be maintained to ensure the status remains adequate.
  • Inactive means a harmonization activity was started, is no longer being actively implemented but should be reinstated.
  • Incomplete means resources to achieve harmonization are available but have not been adequately implemented.
  • Needed means no harmonization activity has been started but one is needed.

The Resources column notes when information on reference materials, reference measurement procedures, and reference laboratory services are listed by JCTLM.

The Organization column provides information on organizations actively addressing harmonization or standardization for the measurand, or developing reference materials or reference measurement procedures for the measurand.

Comments on measurand status can be sent using the Contact Us tab.         Download the form to submit a new measurand.

Summary of Measurand Harmonization Activities

The measurand table is a dynamic information resource. Check regularly for new information.

Click on a measurand to see additional information regarding harmonization status and medical impact.

Click on a link (blue text) for information on a resource or organization.

Click on a single column to sort the table.

Measurand Matrix Medical Impact of Harmonization Harmonization Status Resources Organization
Alkaline Phosphatase (ALP) Serum Medium Incomplete JCTLM   IFCC
Alanine Aminotransferase (ALT) Serum Medium Incomplete JCTLM   IFCC EU-JRC (IRMM)
Albumin Serum Medium Needed JCTLM  
Albumin Urine High Active   NKDEP IFCC JSCC
Alpha Fetoprotein Serum High Adequate/Maintain  
Amylase Serum Low Active JCTLM   IFCC
Anti-DNA antibody (qualitative) Serum Low  
Anti-DNA antibody (quantitative) Serum Medium Needed  
Anti-HBs Qualitative Serum, Plasma High Adequate/Maintain  
Anti-HBs Quantitative Serum, Plasma Medium Needed  
Anti-Hepatitis B core (Anti-HBc total IgM and IgG) Serum, plasma High Adequate/Maintain  
Anti-Hepatitis B Surface Antigen (Anti-HBsAg) Serum, Heparin Plasma High Needed WHO  
Anti-Hepatitis C Virus antibody (Anti-HCV Ab) Serum Medium Adequate/Maintain  
Anti-myeloperoxidase (MPO) antibody, IgG Serum High Needed JCTLM   IFCC
Antinuclear antibody (ANA) fixed cells or serum Active   International Workshops and Consensus Conferences
Anti-SSA antibody IgG Serum Medium Needed  
Antistreptolysin O Serum Low Needed  
Aspartate Aminotransferase (AST) Serum Medium Incomplete JCTLM   IFCC
BCR-ABL1 Whole blood, bone marrow High Adequate/Maintain JCTLM  
Bilirubin, conjugated Serum Medium Needed  
Bilirubin, total Serum High Adequate/Maintain JCTLM  
Blood gasses (pH, pO2, pCO2, oximitry) Blood High Adequate/Maintain  
B-type Natriuretic Peptide (BNP) Serum High Needed  
CA 125 Serum High Needed  
CA 15-3 Serum High Needed  
CA 19-9 Serum High Needed  
Calcium Serum High Adequate/Maintain JCTLM  
Calcium, ionized Blood Medium Needed  
Carbamazepine Serum Medium Adequate/Maintain JCTLM  
Carbohydrate-deficient transferin (CDT) Serum Medium Active JCTLM   IFCC
Carboxyhemoglobin Blood Medium Adequate/Maintain  
Carcinoembrionic antigen (CEA) Serum High Needed  
Chlamydia Trachomatis PCR Urine, Vaginal Swab High Adequate/Maintain  
Chloride Serum Hign Adequate/Maintain JCTLM  
Cholesterol, HDL Serum High Incomplete JCTLM   CDC
Cholesterol, LDL Serum Medium Incomplete JCTLM   CDC
Cholesterol, total Serum High Adequate/Maintain JCTLM   CDC
CO2, Total Serum, Heparin Plasma Medium Needed  
Complement Total (CH50) Serum Medium Needed  
Compliment C3 Serum Medium Active JCTLM  
Compliment C4 Serum Medium Active JCTLM  
Cortisol Serum Medium Incomplete JCTLM   JRC
C-Peptide Serum Medium Active JCTLM   University of Missouri National Metrology Institute of China JCCLS
C-Reactive protein, high sensitivity Serum Medium Adequate/Maintain  
C-Reactive protein, inflammatory Serum Low Incomplete JCTLM   EU-JRC (IRMM)
Creatine Kinase (CK) Serum Medium Incomplete JCTLM   IFCC EU-JRC (IRMM)
Creatinine Serum High Adequate/Maintain JCTLM  
CSF Proteins CSF Medium Active   IFCC
Cyclosporin Blood High Active   IFCC Working Group on Immunosuppressive Drugs
Cytomegalovirus (CMV) Plasma Medium Needed  
Cytomegalovirus IgG (CMV IgG) Serum Medium Adequate/Maintain  
D-dimer plasma High Needed  
Digoxin Serum Medium Needed JCTLM  
Elastase I Fecal, Serum Low Unknown  
Epstein-Barr Virus Blood Medium Active   National Cancer Institute, NIH, USA
Estradiol (17-beta) Serum High Active JCTLM   CDC
Ethyl Alcohol Serum, Plasma Medium Adequate/Maintain JCTLM  
Ferritin Serum, Plasma Medium Adequate/Maintain  
Fetal fibronectin Cervical fluid Low Unknown  
Fibrin Degradation Products (D-dimer) plasma High Needed  
Folate Serum Medium Needed WHO IS 03/178 NIST SRM 3949  
Fructosamine Serum Low Adequate/Maintain  
Gamma glutamyl transferase (GGT) Serum Medium Adequate/Maintain JCTLM  
Gentamicin Serum/plasma Medium Adequate/Maintain JCTLM  
Glucose Serum High Adequate/Maintain JCTLM  
Glucose Urine Low Adequate/Maintain JCTLM CRM JCTLM RMP JCTLM Ref Lab  
Glucose (POCT) Blood High Adequate/Maintain JCTLM  
Glycated Albumin Serum Medium Adequate/Maintain  
Growth Hormone Serum High Active   IFCC
Hematocrit Blood High Adequate/Maintain   ICSH
Hemoglobin Blood High Adequate/Maintain JCTLM as haemiglobincyanide   International Council for Standardization in Haematology
Hemoglobin A1c (HbA1c) Blood High Adequate/Maintain JCTLM   IFCC NGSP
Hemoglobin A2 (HbA2) Serum Medium Active   IFCC
Hemoglobin, fetal (HbF) Blood Low Adequate/Maintain  
Hepatitis B Surface Antigen (HBsAg) Serum, Heparin Plasma High Adequate/Maintain WHO, NIBSC  
Hepatitis C Ab qualitative Serum, Plasma High Adequate/Maintain  
Hepatitis C Virus RNA Serum High Adequate/Maintain  
HIV-1 Genotype Plasma, Dried blood spots High Adequate/Maintain  
HIV-RNA Serum, Plasma High Adequate/Maintain  
Human Chorionic Gonadotropin (hCG) Serum High Needed  
IgE, total Serum Medium Adequate/Maintain  
IgG, Total Serum Medium Adequate/Maintain JCTLM   JRC
IgM, total Serum Medium Adequate/Maintain JCTLM   JRC
IgA, total Serum Medium Adequate/Maintain JCTLM   JRC
Insulin Serum Medium Active   IFCC ADA EASD
Iron Serum Medium Adequare/Maintain  
Iron Binding Capacity (Total): TIBC Serum Low Adequate/Maintain  
Iron binding capacity (unsaturated ) Serum Low Adequate/Maintain  
Iron saturation Serum Low Adequate/Maintain  
Lactate Serum High Adequate/Maintain  
Lactate Dehydrogenase (LDH) Serum Medium Incomplete JCTLM   IFCC IRMM
Lipase Serum Medium Active   IFCC
Lithium Serum, Heparin Plasma High Adequate/Maintain JCTLM  
Lp (a) serum/ plasma High Active   IFCC
Magnesium Serum High Adequate/Maintain JCTLM  
Methemoglobin Blood Low Inactive  
Methotrexate Serum Low Adequate  
Myoglobin Serum, Urine Low Adequate/Maintain  
Neisseria gonorrhea DNA by PCR Urine, Vaginal Swab High Adequate/Maintain  
Osmolality Serum Medium Adequate/Maintain  
Osmolality Urine Medium Adequate/Maintain  
Oxyhemoglobin Blood Medium Adequate/Maintain  
Pancreatic lipase Serum Medium Active   IFCC
Parathyroid hormone (PTH) Serum High Active   IFCC CDC
Phenobarbital Serum, Plasma Medium Adequate/Maintain JCTLM  
Phenytoin Serum Medium Adequate/Maintain JCTLM  
Phosphate Serum Medium Adequate/Maintain  
Platelet Count Blood High Needed JCTLM  
Potassium Serum High Adequate/Maintain JCTLM  
Pregnancy-Associated Plasma Protein A Plasma Active   IFCC
Procalcitonin Serum High Needed  
Prostate Specific Antigen (PSA) Serum High Needed JCTLM  
Protein in CSF CSF Low Active   IFCC
Protein S Serum High Needed   ISTH
Protein, total Urine Low Inactive  
Protein, total Serum Medium Adequate/Maintain  
Pseudocholinesterase Serum Low Adequate/Maintain  
Quinidine Serum/ plasma Low Inactive  
Rheumatoid factor (RF) Serum Low Needed  
Rotavirus Ag Stool High Adequate/Maintain  
Sirolimus Blood High Active JCTLM   IFCC
Sodium Serum High Adequate/Maintain JCTLM  
Syphilis Serum High Adequate/Maintain See Treponema pallidum  
Tacrolimus Blood High Active JCTLM LGC   IFCC Working Group on Immunosuppressive Drugs
Theophylline Serum, heparin plasma Medium Adequate/Maintain JCTLM  
Theophylline Serum, Plasma Medium Adequate/Maintain JCTLM  
Thyroid stimulating hormone (TSH) Serum High Active   IFCC
Thyroxine (T4) Serum High Active JCTLM   IFCC
Thyroxine, free (FT4) Serum High Active   IFCC CDC
Tobramycin Serum/plasma Medium Adequate/Maintain  
Toxoplasma gondii IgG Serum High Adequate/Maintain  
Transferrin Serum Medium Adequate/Maintain JCTLM  
Treponema pallidum Antibodies Serum High Adequate/Maintain WHO International Standard 1st IS for human syphilitic plasma IgG and IgM, code: 05/132  
Triglycerides Serum High Adequate/Maintain JCTLM   CDC
Triiodothyronine, free (FT3) Serum High Needed  
Troponin I, cardiac (cTnI) Serum High Active JCTLM   IFCC
Troponin T Serum High Adequate/Maintain  
Urea N (BUN) Serum Medium Adequate/Maintain JCTLM  
Uric acid Serum Medium Adequate/Maintain JCTLM  
Valproic Acid Serum, Plasma Medium Adequate/Maintain  
Vancomycin Serum Medium Needed JCTLM  
Vitamin B12 Serum Medium Incomplete  
Vitamin D Serum Medium Active JCTLM   National Institutes of Health, USA Centers for Disease Control, USA IFCC