This table provides information on the status of harmonization or standardization of measurands. Additional information regarding the medical impact and harmonization status is available by clicking on the measurand name. The harmonization status shown in the table reflects the situation in economically well developed countries and other geographic areas when measurement procedures supplied by global IVD manufactures are used. The harmonization status may be different when reagents, calibrators and instruments from other suppliers are used.
The medical impact of harmonization, or priority for harmonization, is based on the influence of non-harmonized results on potential medical errors when interpreting a result for a measurand.
Harmonization status:
- Active means an organization is implementing a harmonization project.
- Adequate/Maintain means the current harmonization is suitable for medical decisions and existing reference systems must be maintained to ensure the status remains adequate.
- Inactive means a harmonization activity was started, is no longer being actively implemented but should be reinstated.
- Incomplete means resources to achieve harmonization are available but have not been adequately implemented.
- Needed means no harmonization activity has been started but one is needed.
The Resources column notes when information on reference materials, reference measurement procedures, and reference laboratory services are listed by JCTLM.
The Organization column provides information on organizations actively addressing harmonization or standardization for the measurand, or developing reference materials or reference measurement procedures for the measurand.
Comments on measurand status can be sent using the Contact Us tab. Download the form to submit a new measurand.
Summary of Measurand Harmonization Activities
The measurand table is a dynamic information resource. Check regularly for new information.
Click on a measurand to see additional information regarding harmonization status and medical impact.
Click on a link (blue text) for information on a resource or organization.
Click on a single column to sort the table.
Measurand | Matrix | Medical Impact of Harmonization | Harmonization Status | Resources | Organization |
---|---|---|---|---|---|
Alanine Aminotransferase (ALT) | Serum | Medium | Incomplete | JCTLM | IFCC |
Albumin | Serum | Medium | Needed | JCTLM | IFCC |
Albumin | Urine | High | Active | JCTLM | IFCC |
Alkaline Phosphatase (ALP) | Serum | Medium | Incomplete | JCTLM | IFCC |
Alpha Fetoprotein | Serum | High | Adequate/Maintain | JCTLM | IFCC |
Amylase | Serum | Low | Active | JCTLM | IFCC |
Anti-DNA antibody (qualitative) | Serum | Low | JCTLM | IFCC | |
Anti-DNA antibody (quantitative) | Serum | Medium | Needed | JCTLM | IFCC |
Anti-HBs Qualitative | Serum, Plasma | High | Adequate/Maintain | JCTLM | IFCC |
Anti-HBs Quantitative | Serum, Plasma | Medium | Needed | JCTLM | IFCC |
Anti-Hepatitis B core (Anti-HBc total IgM and IgG) | Serum, plasma | High | Adequate/Maintain | JCTLM | IFCC |
Anti-Hepatitis B Surface Antigen (Anti-HBsAg) | Serum, Heparin Plasma | High | Needed | JCTLM | IFCC |
Anti-Hepatitis C Virus antibody (Anti-HCV Ab) | Serum | Medium | Adequate/Maintain | JCTLM | IFCC |
Anti-myeloperoxidase (MPO) antibody, IgG | Serum | High | Needed | JCTLM | IFCC |
Anti-SSA antibody IgG | Serum | Medium | Needed | JCTLM | IFCC |
Antinuclear antibody (ANA) | fixed cells or serum | Active | JCTLM | IFCC | |
Antistreptolysin O | Serum | Low | Needed | JCTLM | IFCC |
Aspartate Aminotransferase (AST) | Serum | Medium | Incomplete | JCTLM | IFCC |
B-type Natriuretic Peptide (BNP) | Serum | High | Needed | JCTLM | IFCC |
BCR-ABL1 | Whole blood, bone marrow | High | Adequate/Maintain | JCTLM | IFCC |
Bilirubin, conjugated | Serum | Medium | Needed | JCTLM | IFCC |
Bilirubin, total | Serum | High | Adequate/Maintain | JCTLM | IFCC |
Blood gasses (pH, pO2, pCO2, oximitry) | Blood | High | Adequate/Maintain | JCTLM | IFCC |
C-Peptide | Serum | Medium | Active | JCTLM | IFCC |
C-Reactive protein, high sensitivity | Serum | Medium | Adequate/Maintain | JCTLM | IFCC |
C-Reactive protein, inflammatory | Serum | Low | Incomplete | JCTLM | IFCC |
CA 125 | Serum | High | Needed | JCTLM | IFCC |
CA 15-3 | Serum | High | Needed | JCTLM | IFCC |
CA 19-9 | Serum | High | Needed | JCTLM | IFCC |
Calcium | Serum | High | Adequate/Maintain | JCTLM | IFCC |
Calcium, ionized | Blood | Medium | Needed | JCTLM | IFCC |
Carbamazepine | Serum | Medium | Adequate/Maintain | JCTLM | IFCC |
Carbohydrate-deficient transferin (CDT) | Serum | Medium | Active | JCTLM | IFCC |
Carboxyhemoglobin | Blood | Medium | Adequate/Maintain | JCTLM | IFCC |
Carcinoembrionic antigen (CEA) | Serum | High | Needed | JCTLM | IFCC |
Chlamydia Trachomatis PCR | Urine, Vaginal Swab | High | Adequate/Maintain | JCTLM | IFCC |
Chloride | Serum | High | Adequate/Maintain | JCTLM | IFCC |
Cholesterol, HDL | Serum | High | Incomplete | JCTLM | IFCC |
Cholesterol, LDL | Serum | Medium | Incomplete | JCTLM | IFCC |
Cholesterol, total | Serum | High | Adequate/Maintain | JCTLM | IFCC |
CO2, Total | Serum, Heparin Plasma | Medium | Needed | JCTLM | IFCC |
Complement Total (CH50) | Serum | Medium | Needed | JCTLM | IFCC |
Compliment C3 | Serum | Medium | Active | JCTLM | IFCC |
Compliment C4 | Serum | Medium | Active | JCTLM | IFCC |
Cortisol | Serum | Medium | Incomplete | JCTLM | IFCC |
Creatine Kinase (CK) | Serum | Medium | Incomplete | JCTLM | IFCC |
Creatinine | Serum | High | Adequate/Maintain | JCTLM | IFCC |
CSF Proteins | CSF | Medium | Active | JCTLM | IFCC |
Cyclosporin | Blood | High | Active | JCTLM | IFCC |
Cytomegalovirus (CMV) | Plasma | Medium | Needed | JCTLM | IFCC |
Cytomegalovirus IgG (CMV IgG) | Serum | Medium | Adequate/Maintain | JCTLM | IFCC |
D-dimer | plasma | High | Needed | JCTLM | IFCC |
Digoxin | Serum | Medium | Needed | JCTLM | IFCC |
Elastase I | Fecal, Serum | Low | Unknown | JCTLM | IFCC |
Epstein-Barr Virus | Blood | Medium | Active | JCTLM | IFCC |
Estradiol (17-beta) | Serum | High | Active | JCTLM | IFCC |
Ethyl Alcohol | Serum, Plasma | Medium | Adequate/Maintain | JCTLM | IFCC |
Ferritin | Serum, Plasma | Medium | Adequate/Maintain | JCTLM | IFCC |
Fetal fibronectin | Cervical fluid | Low | Unknown | JCTLM | IFCC |
Fibrin Degradation Products (D-dimer) | plasma | High | Needed | JCTLM | IFCC |
Folate | Serum | Medium | Needed | JCTLM | IFCC |
Fructosamine | Serum | Low | Adequate/Maintain | JCTLM | IFCC |
Gamma glutamyl transferase (GGT) | Serum | Medium | Adequate/Maintain | JCTLM | IFCC |
Gentamicin | Serum/plasma | Medium | Adequate/Maintain | JCTLM | IFCC |
Glucose | Serum | High | Adequate/Maintain | JCTLM | IFCC |
Glucose | Urine | Low | Adequate/Maintain | JCTLM | IFCC |
Glucose (POCT) | Blood | High | Adequate/Maintain | JCTLM | IFCC |
Glycated Albumin | Serum | Medium | Adequate/Maintain | JCTLM | IFCC |
Growth Hormone | Serum | High | Active | JCTLM | IFCC |
Hematocrit | Blood | High | Adequate/Maintain | JCTLM | IFCC |
Hemoglobin | Blood | High | Adequate/Maintain | JCTLM | IFCC |
Hemoglobin A1c (HbA1c) | Blood | High | Adequate/Maintain | JCTLM | IFCC |
Hemoglobin A2 (HbA2) | Serum | Medium | Active | JCTLM | IFCC |
Hemoglobin, fetal (HbF) | Blood | Low | Adequate/Maintain | JCTLM | IFCC |
Hepatitis B Surface Antigen (HBsAg) | Serum, Heparin Plasma | High | Adequate/Maintain | JCTLM | IFCC |
Hepatitis C Ab qualitative | Serum, Plasma | High | Adequate/Maintain | JCTLM | IFCC |
Hepatitis C Virus RNA | Serum | High | Adequate/Maintain | JCTLM | IFCC |
HIV-1 Genotype | Plasma, Dried blood spots | High | Adequate/Maintain | JCTLM | IFCC |
HIV-RNA | Serum, Plasma | High | Adequate/Maintain | JCTLM | IFCC |
Human Chorionic Gonadotropin (hCG) | Serum | High | Needed | JCTLM | IFCC |
IgA, total | Serum | Medium | Adequate/Maintain | JCTLM | IFCC |
IgE, total | Serum | Medium | Adequate/Maintain | JCTLM | IFCC |
IgG, Total | Serum | Medium | Adequate/Maintain | JCTLM | IFCC |
IgM, total | Serum | Medium | Adequate/Maintain | JCTLM | IFCC |
Insulin | Serum | Medium | Active | JCTLM | IFCC |
Iron | Serum | Medium | Adequate/Maintain | JCTLM | IFCC |
Iron Binding Capacity (Total): TIBC | Serum | Low | Adequate/Maintain | JCTLM | IFCC |
Iron binding capacity (unsaturated ) | Serum | Low | Adequate/Maintain | JCTLM | IFCC |
Iron saturation | Serum | Low | Adequate/Maintain | JCTLM | IFCC |
Lactate | Serum | High | Adequate/Maintain | JCTLM | IFCC |
Lactate Dehydrogenase (LDH) | Serum | Medium | Incomplete | JCTLM | IFCC |
Lipase | Serum | Medium | Active | JCTLM | IFCC |
Lithium | Serum, Heparin Plasma | High | Adequate/Maintain | JCTLM | IFCC |
Lp (a) | serum/ plasma | High | Active | JCTLM | IFCC |
Magnesium | Serum | High | Adequate/Maintain | JCTLM | IFCC |
Methemoglobin | Blood | Low | Inactive | JCTLM | IFCC |
Methotrexate | Serum | Low | Adequate | JCTLM | IFCC |
Myoglobin | Serum, Urine | Low | Adequate/Maintain | JCTLM | IFCC |
Neisseria gonorrhea DNA by PCR | Urine, Vaginal Swab | High | Adequate/Maintain | JCTLM | IFCC |
Osmolality | Serum | Medium | Adequate/Maintain | JCTLM | IFCC |
Osmolality | Urine | Medium | Adequate/Maintain | JCTLM | IFCC |
Oxyhemoglobin | Blood | Medium | Adequate/Maintain | JCTLM | IFCC |
Pancreatic lipase | Serum | Medium | Active | JCTLM | IFCC |
Parathyroid hormone (PTH) | Serum | High | Active | JCTLM | IFCC |
Phenobarbital | Serum, Plasma | Medium | Adequate/Maintain | JCTLM | IFCC |
Phenytoin | Serum | Medium | Adequate/Maintain | JCTLM | IFCC |
Phosphate | Serum | Medium | Adequate/Maintain | JCTLM | IFCC |
Platelet Count | Blood | High | Needed | JCTLM | IFCC |
Potassium | Serum | High | Adequate/Maintain | JCTLM | IFCC |
Pregnancy-Associated Plasma Protein A | Plasma | Active | JCTLM | IFCC | |
Procalcitonin | Serum | High | Needed | JCTLM | IFCC |
Prostate Specific Antigen (PSA) | Serum | High | Needed | JCTLM | IFCC |
Protein in CSF | CSF | Low | Active | JCTLM | IFCC |
Protein S | Serum | High | Needed | JCTLM | IFCC |
Protein, total | Urine | Low | Inactive | JCTLM | IFCC |
Protein, total | Serum | Medium | Adequate/Maintain | JCTLM | IFCC |
Pseudocholinesterase | Serum | Low | Adequate/Maintain | JCTLM | IFCC |
Quinidine | Serum/ plasma | Low | Inactive | JCTLM | IFCC |
Rheumatoid factor (RF) | Serum | Low | Needed | JCTLM | IFCC |
Rotavirus Ag | Stool | High | Adequate/Maintain | JCTLM | IFCC |
Sirolimus | Blood | High | Active | JCTLM | IFCC |
Sodium | Serum | High | Adequate/Maintain | JCTLM | IFCC |
Syphilis | Serum | High | Adequate/Maintain | JCTLM | IFCC |
Tacrolimus | Blood | High | Active | JCTLM | IFCC |
Theophylline | Serum, heparin plasma | Medium | Adequate/Maintain | JCTLM | IFCC |
Theophylline | Serum, Plasma | Medium | Adequate/Maintain | JCTLM | IFCC |
Thyroid stimulating hormone (TSH) | Serum | High | Active | JCTLM | IFCC |
Thyroxine (T4) | Serum | High | Active | JCTLM | IFCC |
Thyroxine, free (FT4) | Serum | High | Active | JCTLM | IFCC |
Tobramycin | Serum/plasma | Medium | Adequate/Maintain | JCTLM | IFCC |
Toxoplasma gondii IgG | Serum | High | Adequate/Maintain | JCTLM | IFCC |
Transferrin | Serum | Medium | Adequate/Maintain | JCTLM | IFCC |
Treponema pallidum Antibodies | Serum | High | Adequate/Maintain | JCTLM | IFCC |
Triglycerides | Serum | High | Adequate/Maintain | JCTLM | IFCC |
Triiodothyronine, free (FT3) | Serum | High | Needed | JCTLM | IFCC |
Troponin I, cardiac (cTnI) | Serum | High | Active | JCTLM | IFCC |
Troponin T | Serum | High | Adequate/Maintain | JCTLM | IFCC |
Urea N (BUN) | Serum | Medium | Adequate/Maintain | JCTLM | IFCC |
Uric acid | Serum | Medium | Adequate/Maintain | JCTLM | IFCC |
Valproic Acid | Serum, Plasma | Medium | Adequate/Maintain | JCTLM | IFCC |
Vancomycin | Serum | Medium | Needed | JCTLM | IFCC |
Vitamin B12 | Serum | Medium | Incomplete | JCTLM | IFCC |
Vitamin D | Serum | Medium | Active | JCTLM | IFCC |