This section provides information on the status of harmonization or standardization of measurands. Priorities based on medical impact are provided for measurands for which harmonization is needed or that have an incomplete or inactive implementation of a harmonization activity.  Additional information regarding the harmonization status and medical impact is available by clicking on the measurand name. The Resources column notes when information on reference materials, reference measurement procedures, and reference laboratory services are listed by JCTLM. The Organization column provides information and links to organizations actively addressing harmonization or standardization for the measurand.

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Summary of Measurand Harmonization Activities

The measurand table is a dynamic information resource. Check regularly for new information.

Click on a measurand to see additional information regarding harmonization status and medical impact.

Click on a link for information on those resources.

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Measurand Matrix Medical Impact of Harmonization1 Harmonization Status2 Resources3 Organization4
Akaline Phosphatase (ALP) Serum Medium Incomplete JCTLM     IFCC  
Alanine Aminotransferase (ALT) Serum Medium Incomplete JCTLM     IFCC   EU-JRC (IRMM)  
Albumin Serum Medium Needed JCTLM      
Albumin Urine Active   NKDEP   IFCC   JSCC  
Alpha Fetoprotein Serum Adequate    
Amylase Serum Active JCTLM     IFCC  
Anti-DNA antibody (qualitative) Serum Low    
Anti-DNA antibody (quantitative) Serum Medium Needed    
Anti-Hepatitis C Virus antibody (Anti-HCV Ab) Serum Adequate    
Antinuclear antibody (ANA) fixed cells or serum Active   International Workshops and Consensus Conferences  
Antistreptolysin O Serum Low Needed    
Aspartate Aminotransferase (AST) Serum Medium Incomplete JCTLM     IFCC  
Bilirubin, conjugated Serum Medium Needed    
Bilirubin, total Serum Adequate JCTLM      
Blood gasses (pH, pO2, pCO2, oximitry) Blood Adequate    
B-type Natriuretic Peptide (BNP) Serum High Needed    
CA 125 Serum High Needed    
CA 15-3 Serum High Needed    
CA 19-9 Serum High Needed    
Calcium Serum Adequate JCTLM      
Calcium, ionized Blood Medium Needed      
Carbamazepine Serum Adequate JCTLM      
Carbohydrate-deficient transferin (CDT) Serum Active JCTLM     IFCC  
Carboxyhemoglobin Blood Adequate    
Carcinoembrionic antigen (CEA) Serum High Needed    
Chloride Serum Adequate JCTLM      
Cholesterol, HDL Serum High Incomplete JCTLM     CDC  
Cholesterol, LDL Serum Medium Incomplete JCTLM     CDC  
Cholesterol, total Serum Adequate JCTLM     CDC  
CO2, Total Serum, Heparin Plasma Medium Needed    
Compliment C3 Serum Medium Active JCTLM      
Compliment C4 Serum Medium Active JCTLM      
Cortisol Serum Medium Incomplete JCTLM   JRC      
C-Peptide Serum Active JCTLM     University of Missouri   National Metrology Institute of China   JCCLS  
C-Reactive protein, high sensitivity Serum Adequate    
C-Reactive protein, inflammatory Serum Low Incomplete JCTLM     EU-JRC (IRMM)  
Creatine Kinase (CK) Serum Incomplete JCTLM     IFCC   EU-JRC (IRMM)  
Creatine Kinase-MB (CK-MB) Serum Adequate    
Creatinine Serum Adequate JCTLM      
CSF Proteins CSF Active   IFCC  
Cytomegalovirus (CMV) Plasma Medium Needed    
Cytomegalovirus IgG (CMV IgG) Serum Adequate    
D-dimer plasma High Needed    
Digoxin Serum Medium Needed JCTLM      
Epstein-Barr Virus Blood Active   National Cancer Institute, NIH, USA  
Ethyl Alcohol Serum, Plasma Adequate JCTLM      
Ferritin Serum, Plasma Adequate    
Fibrin Degradation Products (D-dimer) plasma High Needed    
Folate Serum Active   CDC   NIST  
Fructosamine Serum Adequate    
Gamma glutamyl transferase (GGT) Serum Adequate JCTLM      
Glucose Serum Adequate JCTLM      
Glucose (POCT) Blood Adequate JCTLM      
Glycated Albumin Serum Adequate    
Growth Hormone Serum Active   IFCC  
HBV Ag and anti-HBs Ab Serum Adequate    
Hemoglobin A1c (HbA1c) Blood Adequate JCTLM     IFCC   NGSP  
Hemoglobin A2 (HbA2) Serum Active   IFCC  
Hemoglobin, fetal (HbF) Blood Adequate    
Hepatitis C Virus RNA Serum Adequate    
HIV-1 Ag with HIV-1 and HIV-2 Abs Serum Adequate    
HIV-RNA Serum, Plasma Adequate    
Human Chorionic Gonadotropin (hCG) Serum High Needed    
IgE, total Serum Adequate    
IgG antibodies to myeloperoxidase Serum Active    
Insulin Serum Active   IFCC   ADA   EASD  
Iron binding capacity (unsaturated ) Serum Adequate    
Lactate Serum Adequate    
Lactate Dehydrogenase (LDH) Serum Incomplete JCTLM     IFCC   IRMM  
Lipase Serum Active   IFCC  
Lithium Serum, Heparin Plasma Adequate JCTLM      
Magnesium Serum Adequate JCTLM      
Myoglobin Serum, Urine Adequate    
NT-proBNP Serum Adequate    
Oxyhemoglobin Blood Adequate    
pancreatic lipase Serum Active   IFCC  
Parathyroid hormone (PTH) Serum Active   IFCC  
Phenytoin Serum Adequate JCTLM      
Phosphate Serum Adequate    
Potassium Serum Adequate JCTLM      
Pregnancy-Associated Plasma Protein A Plasma Active   IFCC  
Procalcitonin Serum High Needed    
Prostate Specific Antigen (PSA) Serum High Needed JCTLM      
Protein in CSF CSF Low Active   IFCC  
Protein S Serum High Needed   ISTH  
Protein, total Serum Adequate    
Rheumatoid factor (RF) Serum Low Needed    
Rotavirus Ag Stool Adequate    
Sodium Serum Adequate JCTLM      
Thyroid stimulating hormone (TSH) Serum Active   IFCC  
Thyroxine (T4) Serum Active JCTLM     IFCC  
Thyroxine, free (FT4) Serum Active   IFCC  
Treponema pallidum (syphilis) Serum Adequate    
Triglycerides Serum Adequate JCTLM     CDC  
Triiodothyronine, free (FT3) Serum High Needed    
Troponin I, cardiac (cTnI) Serum Active JCTLM     IFCC  
Troponin T Serum Adequate    
Urea N (BUN) Serum Adequate JCTLM      
Uric acid Serum Adequate JCTLM      
Vancomycin Serum Medium Needed JCTLM      

Low, medium and high refer to the medical impact of the current inadequate harmonization on potential medical errors in interpreting a result for a measurand.

Harmonization status: Active means an organization is implementing a harmonization project; Adequate means the current harmonization is suitable for medical decisions; Inactive means a harmonization activity was started but is no longer being actively implemented; Incomplete means resources to achieve harmonization are available but have not been adequately implemented; Needed means no harmonization activity has been started but one is needed.

Resources:  JCTLM indicates a reference material, reference measurement procedure, or reference measurement service is listed by the Joint Committee for Traceability in Laboratory Medicine. Other names indicate providers of PT/EQA surveys that use commutable samples.

Organizations addressing harmonization or standardization for the measurand.